COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status,
a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: (125 nmol/L)
Results of a Systematic Review and Meta-Analysis
https://www.mdpi.com/2072-6643/13/10/3596
Blood calcifediol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity
Cause or effect?
Strength of our immune system,
More or less neglected by the responsible authorities
Nutrition, physical fitness, recreation, sleep
Widespread vitamin D deficiency
Data collected March 2021
Methods
Systematic literature search
Retrospective cohort studies (1)
Clinical studies (7) on COVID-19 mortality rates versus D3 blood levels
Reported D3 blood levels pre-infection or on the day of hospital admission
Mortality rates, corrected for age, sex, and diabetes
Results
Negative Pearson correlation of D3 levels and mortality risk
r = −0.4154, p = 0.0770
r = −0.4886, p = 0.0646
Combined data
Median D3 levels were 23.2 ng/mL (58 nmol/L)
Pearson correlation = −0.3989, p = 0.0194
Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL (125 nmol/L) D3
Conclusions
The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection.
Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL
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